Myeloproliferative disorders

The use of androgen therapy in other causes of bone marrow failure has been less extensively studied. One controlled study of 29 patients with myeloproliferative disorders randomised patients to treatment with fluoxymesterone (30 mg daily) compared with transfusions alone but was terminated prematurely due to slow recruitment and poor hemoglobin response with only 4/14 achieving an increase of >10 g/l (Brubaker etal. 1982). These findings are supported by another randomised study of 56 patients with myelodysplasia which found oral methenolone acetate (2.5 mg/kg/day) no better than intravenous cytosine arabinoside or symptomatic maintenance therapy (Najean and Pecking 1979).

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