Red cell glycolysis

Erythrocyte-uptake of glucose subsequently results in glycolysis providing energy via phosphorylation products to enhance the activity of the general transcription machinery. This process is a prerequisite for red blood cell proliferation and is effective after 8-12 hours of glucose utilization (Molinari et al. 1976). Androgens can enhance the uptake of glucose (Molinari et al. 1976) once they have permeated the cell membrane, a process which is independent of various types ofhemoglobin (Molinari 1982). In humans, oral ingestion of oxymetholone, a synthetic androgen, resulted in an increased rate of erythrocyte glycolysis as measured by quantitative determination of: fructose-1,6-diphosphate, dehydroxyace-tone phosphate, 2,3-diphosphoglycerate and adenosine triphosphate as glycolysa-tion products (Molinari and Neri 1978). Correspondingly, specific changes occure in the erythroid tissue following depletion of androgens, as studied in rats. The reduction of testosterone levels in the blood of orchiectomized animals caused a decline of erythrocyte glucose-6-phosphate and lactate levels. Subcutaneous administration of testosterone propionate to these animals restored parameters within 12 hours (Molinari etal. 1976).

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