Andersson S, Moghrabi N (1997) Physiology and molecular genetics of 17ß- hydroxysteroid dehydrogenases. Steroids 62:143-147 Ariyaratne HBS, Mills N, Mason JI, Mendis-Handagama SMLC (2000) Effects ofthyroid hormone on leydig cell regeneration in the adult rat following ethane dimethane sulphonate treatment. Biol Reprod 63:1115-1123 Ascoli M, Fanelli F, Segaloff DL (2002) The lutropin/choriogonadotropin receptor, a 2002 perspective. Endocr Rev 23:141-174 Baker J, Hardy MP, Zhou J, Bondy C, Lupu F, Bellve AR, Efstratiadis A (1996) Effects of an IGF-1

gene null mutation on mouse reproduction. Molec Endocr 10:903-918 Baker PJ, Pakarinen P, Hutaniemi IT, Abel MH, Charlton HM, Kumar TR, Shaughnessy PJ (2003). Failure of normal Leydig cell development in follicle-stimulating hormone (FSH) receptor-deficient mice, but not FSHbeta-deficient mice: role for constitutive FSH receptor activity. Endocrinology 144:138-145 Baulieu EE (1997) Neurosteroids: of the nervous system, by the nervous system, for the nervous system. In: Rec Prog Horm Res 52: pp 1-32 Benten WPM, Lieberherr, M, Sekeris CE, Wunderlich F (1997) Testosterone induces Ca2+ influx via non-genomic surface receptors in activated T cells. FEBS Letters 407:211-214 Berridge MJ, Galione A (1988) Cytosolic calcium oscillators. Fed Proc Am Soc Exp Biol 2: 3074-3082

Besa CE, Bullock LP (1981) The role of the androgen receptor in erythropoiesis. Endocrinology 109:1983-1989

Biswas MG, Russell DW (1997) Expression cloning and characterization of oxidative 17ß- and 3a-hydroxysteroid dehydrogenases from rat and human prostate. J Biol Chem 272:1595915966

Brinkmann AO, Leemborg FG, Rommerts FFG, van der Molen HJ (1982) Translocation of the testicular oestradiol receptor is not an obligatory step in the gonadotropin-induced inhibition ofC17-20-lyase. Endocrinology 110:1834-1836 Bulun SE (1996) Aromatase deficiency in women and men: would you have predicted the phe-

notypes? J Clin Endocr Metab 81:867-871 Calvo JC, Radicella JP, Pignataro OP, Charreau EH (1984) Effect of a second injection of human chorionic gonadotrophin on the desensitized Ley dig cells. Mol Cell Endocr 34:31-38 Castoria G, Lombardi M, Barone MV, Bilancio A, Domenico MD, Bottero D, Vitale F, Migliac-chio A, Aurricchio F (2003) Androgen-stimulated DNA synthesis and cytoskeletal changes in fibroblast by a nontranscriptional receptor action. J Cell Biol 161:547-556 Chemes HE (1996) Leydig cell development in humans. In: Payne AH, Hardy MP, Russell LD

(eds) The Leydig cell. Cache River Press, Vienna, Il pp 176-202 Chen HL, Zirkin BR (1999) Long term suppression of Leydig cell steroidogenesis prevents Leydig cell aging. Proc Natl Acad Sci USA 96:14877-14881 Chen HL, Hardy MP, Zirkin BR (2002) Agerelateddecreasesin Leydig cell testosterone production are not restored by exposure to LH in vitro. Endocrinology 143:1637-1642 Clark BJ, Soo SC, Caron KM, IkedaY, Parker KL, Stocco DM (1995) Hormonal anddevelopmental regulation ofthe steroidogenic acute regulatory (StAR) protein. Mol Endocrinol 9:1346-1355 Coffey DS (1988) Androgen action and the sex accessory tissues. In: Knobil E, Neill (eds) The physiology of reproduction. J. Raven Press, New York, pp 1081-1119 Collett-Solberg PF, Cohen P (1996) The role of the insulin-like growth factor binding proteins and the IGFBP proteases in modulation IGF action. Endocrinol Metab Clin North America 25:591-614

Combarnous Y, Guillou F, Martinat N (1986) Functional states of the luteinizing hormone/

choriogonadotropin-receptor complex in rat Leydig cells. J Biol Chem 261:6868-71 Comfort A (1971) Likelihood of human pheromones. Nature 230:432-433 Cooke BA (1996) Transduction ofthe luteinizing hormone signal within the Leydig cell. In: Payne

AH, Hardy MP, Russell LD (eds) The Leydig cell. Cache River Press, Vienna, Il, pp 352-366 Coquelin A, Desjardins C (1982) Luteinizing hormone and testosterone secretion in young and old male mice. Am J Physiol 243:E257-E263 Cowley JJ, Brooksbank BW (1991) Human exposure to putative pheromones and changes in aspects of social behaviour. J Steroid Biochem Mol Biol 39:647-59 Csaba Z, Csernus V, Gerendai I (1998) Intratesticular serotonin affects steroidogenesis in the rat testis. J Neuroendocrinol 10:371-376 De Ronde W, Pols HAP, Johannes PTM, van Leeuwen PTM, de Jong FH (2003) The importance of oestrogens in males. Clin Endocr 58:529-542 Dumont JE, Pecasse F, Maenhaut C (2001) Crosstalk and specificity in signaling, are we crosstalk-

ing ourselves into general confusion? Cell Signalling 13:457-463 Ewing LL, Zirkin B (1983) Leydig cell structure and steroidogenic function. Rec Progr Horm Res 39:599-635

Forest MG (1989) Physiological changes in circulating androgens Pediatr Adolesc Endocrinol 19:104-129

Freeman DA, Rommerts FFG (1996) Regulation of Leydig cell cholesterol transport. In: Payne

AH, Hardy MP, Russell LD (eds) The Leydig cell. Cache River Press, Vienna, Il pp 232-239 Gao HB, Tong MH, Hu YQ, Guo QS, Ge R, Hardy MP (2002) Glucocorticoid induces apoptosis in rat Leydig cells. Endocrinology 143:130-138 Geissler WM, Davis DL, Wu l, Bradshaw KD, Patel S, Mendonca BB, Elliston KO, Wilson JD, Russell DW, Andersson S (1994) Male pseudohermaphroditism caused by mutations of testicular 17ß-hydroxysteroid dehydrogenase 3. Nature Genet 7:4-39 George FW (1997) Androgen metabolism in the prostate of the finasteride treated adult rat: a possible explanation for the differential action of testosterone and 5a-dihydrotestosterone during development of the male urogenital tract. Endocrinology 138:871-877 Gnessi L, Fabri A, Spera G (1997) Gonadal peptides as mediators of development and functional control of the testis: An integrated system with hormones and local environment. Endocr Rev 18:541-609

Gower DB, Cooke GM (1983) Regulation of steroid-transforming enzymes by endogenous steroids. J Steroid Biochem 19:1527-1556 Gruol DJ, Bourgeois S (1997) Chemosensitizing steroids: glucocorticoid receptor agonists capable of inhibiting P-glycoprotein function. Cancer Res 54:720-727 Guo Z, Benten WP, Krucken J, Wunderlich F (2002) Nongenomic testosterone calcium signaling. Genotropic actions in androgen receptor-free macrophages. J Biol Chem 277:2960029607

Hakola K, Pierroz DD, Aebi A, Vuagnat BAM, Aubert ML, Huhtaniemi I (1998) Dose and time relationships of intravenously injected rat recombinant luteinizing hormone and testicular testosterone secretion in the male rat. Biol Reprod 59:338-343 Hall, PF (1988). Testicular steroid synthesis: organization and regulation. In: Knobil E, Neill J

(eds) The physiology of reproduction, Raven Press, New York pp 975-998 Hall PF (1991) Cytochrome P450 C21scc: one enzyme with two actions: hydroxylase and lyase.

J Steroid Biochem Mol Biol 40:527-532 Hammond GL, Ruokonen A, Kontturi M, Koskela E, Vihko R (1977) The simultaneous radioim-munoassay of seven steroids in human spermatic and peripheral venous blood. J Clin Endocrinol Metab 45:16-24 Haour F, Kovanetzova B, Dray F, Saez JM (1979) hCG induced prostaglandin E2 and F2a release in adult rat testis: role in Leydig cell desensitization to hCG. Life Sci, 24:2151-2158 HasegawaT, Zhao LP, Caron KM,MajdicG, SuzukiT, ShizawaS, Parker KL (2000) developmental roles of the steroidogenic acute regulatory protein (StAR) as revealed by StAR knockout mice. Mol Endocrinol 14:1462-1471 Heinlein CA, Chang C (2002) The roles of androgen receptors and androgen-binding proteins in nongenomic androgen actions. Mol Endocrinol 16:2181-2187 Hodgson YM, de Kretser DM (1984) Acute responses of Leydig cells to hCG: evidence for early hypertrophy of Leydig cells. Mol Cell Endocr 35:75-82 Huhtaniemi, I. (1996) Ontogeny of the luteinizing hormone action in the male. In: Payne AH, Hardy MP, Russell LD (eds) The Leydig cell. Cache River Press, Vienna, Il, pp 365-382

HuhtaniemiI, Bolton NJ, Martikainen H, VihkoR (1983) Comparison of serum steroid responses to a single injection of hCG in man and rat. J Steroid Biochem 19:1147-1151 Hunzicker-Dunn M, Gurevich VV, Casanova JE, Mukherjee S (2002) ARF6: a newly appreciated player in G protein-coupled receptor desensitization. FEBS letters 521:3-8 Ishimaru T, Pages L, Horton R (1977) Altered metabolism of androgens in elderly men with benign prostatic hyperplasia. J Clin Endocrinol Metab 45:695-701 King SR, Manna, PR, Ishii T, Syapin PJ, Ginsberg SD, Wilson K, Walsh LP, Parker KL, Stocco DM, Smith, RG, Lamb DJ (2002) An essential component in steroid synthesis, the steroidogenic acute regulatory protein, is expressed in discrete regions of the brain. J Neurosci 22: 10613-10620

Labrie F, Luu-The V, Lin SX, Labrie C, Simard J, Breton R, Belanger A (1997) The key role of

17^-hydroxysteroid dehydrogenases in sex steroid biology. Steroids 62:148-158 Lachane Y, Luu-The V, Labrie C, Simard C, Dumont M, de Launou Y, Guerin S, Leblanc G, Labrie F (1990) Chracterization of the structure-actvity relationship of rat types I and II 3p hydroxysteroid dehydrogenase/ 5- 4 -isomerase gene and its expression in mammalian cells. J Biol Chem 265:20469-20475 Laurich VM, Trbovich AM, O'Neill FH, Houk CP, Sluss PM, Payne AH, Donahoe PK, Teixeira J (2002) Mullerian inhibiting substance blocks the protein kinase A-induced expression of cytochrome p450 17alpha-hydroxylase/C(17-20) lyase mRNA in a mouse Leydig cell line independent of cAMP responsive element binding protein phosphorylation. Endocrinology 143:3351-3360

Lin T (1996) Insulin-like growth factor-I regulation of the Leydig cell In The Leydig cell, (ed)

Payne AH, Hardy MP, Russell LD Cache River Press, Vienna, Il, pp 478-491 Loosfelt H, Misrahi M, Atger M, Salesse R, Thi MTVHL, Jolivet A, Guiochon-Mantel A, Sar S, Jallal B, Garnier J, Milgrom E (1989) Cloning and sequencing of porcine LH-hCG receptor cDNA: variants lacking transmembrane domain. Science 245:525-528 Lubicz-Nawrocki CM (1973) The effect of metabolites of testosterone on the viability of hamster epididymal spermatozoa. J Endocrinol 58:193-198 Luke MC, Coffey DS (1994) The male sex accessory tissues: structure, androgen action and physiology. In The physiology of reproduction, Knobil E, Neill JD (eds), Raven Press, New York, pp 1435-1480

Luu-The V, Takahashi Y, de Lanoit M, Dumont M, Lachane Y, Labrie F (1991) Evidence for distinct dehydrogenase and isomerase sites within a single 3^-hydroxysteroid dehydrogenase 5-ene-4-ene isomerase protein. Biochemistry 30:8861-8865 Lyng FM, Jones GR, Rommerts FFG (2000) Rapid androgen actions on calcium signaling in rat Sertoli cells and two human prostatic cell lines, similar biphasic responses between 1 picomolar and 100 nanomolar concentrations. Biol Reprod 63:736-747 Maddocks S, Sharpe RM (1989) Dynamics of testosterone secretion by the rat testis: implications for measurement of the intratesticular levels of testosterone. J Endocr 122:323-329 Manna PR, Tena-Sempere M, Hutaniemi IT (1999) Molecular mechanisms of thyroid hormone-stimulated steroidogenesis in mouse leydig tumor cells-involvement of the steroidogenic acute regulatory (StAR) protein. J Biol Chem 274:5909-5918

McFarland KC, Sprengel R, Phillips HS, Koher M, Rosemblit N, Nikolics K, Segaloff DL, Seeburg PH (1989) Lutropin-choriogonadotropin receptor: an unusual member of the G proteincoupled receptor family. Science 245:494-499 Mendel CM (1989) The free hormone hypothesis: a physiologically based mathematical model. Endocr Rev 10:232-274

Mendel CM, Murai JT, Siiteri PK, Monroe SE, Inove M (1989) Conservation of free but not total or non-sex-hormone binding-globulin-bound testosterone in serum from nagase anal-buminemic rats. Endocrinology 124:3128-3130 Monno S, Ogawa H, Date T, Fujioka WL, Millar WL, Kobayashi M (1993) Mutation of histi-dine -373 to leucine in cytochrome-P450c17 causes 17a hydroxylase deficiency. J Biol Chem 268:25811-25817

Michael RP, Bonsall RW, Rees HD (1986) Accumulation of 3H testosterone and 3H estradiol in the brain of the female primate: evidence for the aromatization hypothesis. Endocrinology 118:1935-1944

Miller WL (1988) Molecular biology of steroid hormone synthesis. Endocr Rev 9:295318

Miura T, Yamauchi K, Takahashi H, Nagahama Y (1991) Hormonal induction of all stages of spermatogenesis in vitro in the male Japanese eel (Anguilla japonica). Proc Natl Acad Sci USA 88:5774-5778

Miautani S, Tsujimura T, Akashi S, Matsumoto K (1977) Lack of metabolism of progesterone, testosterone and pregnenolone to 5a-products in monkey and human testes compared with rodent testes. J Clin Endocrinol Metab 44:1023-1031 Mooradian AD, Morley JE, Korenman SG (1987) Biological actions of androgens. Endocr Rev 8:1-27

Morishima A, Grumbach MM, Simpson ER, Fisher C, Qin K (1995) Aromatase deficiency in male and female siblings caused by a novel mutation and the physiological role of oestrogens. J Clin Endocr Metab 80:3689-3698 Mulder E, Lamers-Stahlhofen GJM, van der Molen HJ (1973) Interaction between steroids and membranes. Uptake of steroids and steroid sulphates by resealed erythrocyte ghosts. J Steroid Biochem 4:369-379

Noordhuizen-Stassen EW, Charbon GA, de Jong FH, Wensing CJG (1985) Functional arteriovenous anastomoses between the testicular artery and the pampiniform plexus in the spermatic cord of rams. J Reprod Fert 75:193-201 OdellWD, Swerdloff RS, Jacobs HS, HescoxMA (1973) FSH induction of sensitivity to LH; one cause of sexual maturation in the male rat. Endocrinology 92:160-165 O'Malley BW, Schrader WT, Mani S, Smith C, Weigel NL, Conneely OM, Clark JH (1995) An alternative ligand-independent pathway for activation of steroid receptors. Rec Prog Horm Res 50:333-353

Pandey AV, Mellon SH, Miller WL (2003) Protein phosphatase 2A and phosphoprotein SET

regulate androgen production by P450c17. J Biol Chem 278:2837-2844 Papadopoulos V. (1993) Peripheral-type benzo-diazepine/diazepam binding inhibitor receptor: biological role in steroidogenic cell function. Endocr Rev 14:22-240

Papakonstanti EA, Kampa M, Castanas E, Stournaras C (2003) A rapid nongenomic, signalling pathway regulates the actin reorganization induced by activation of membrane testosterone receptors. Mol Endocrinol 17:870-881 Parker KL, Schimmer BP (1997) Steroidogenic factor 1: A key determinant of endocrine development and function. Endocr Rev 18:361-377 Payne AH, Quinn PG, Rani CSS (1985) Regulation of microsomal cytochrome P-450 enzymes and testosterone production in Ley dig cells. Rec Progr Horm Res 41:153-185 Payne AH, Hardy MP, Russell LD (eds) (1996) The Ley dig cell. Cache River Press, Vienna, IL Payne AH, O'Shaughnessy P (1996) Structure,function,and regulation of steroidogenic enzymes in the Ley dig cell. In: The Leydig cell. Payne AH, Hardy MP, Russell LD (eds), Cache River Press, Vienna, IL. pp 260-285 Penning TM (1997) Molecular endocrinology of hydroxysteroiddehydrogenases. Endocr Reviews 18:281-305

Rao RM, Jo Y, Leers-Sucheta S, Bose HS, Miller W, Azhar S, Stocco DM (2003) Differential regulation of steroid hormonebiosynthesis in R2C and MA-10 Leydig tumor cells: Role of SR-B1- mediated selective cholesteryl ester transport. Biol Reprod 68:114-121 Rice DA, Mouw AR, Bogerd AM, Parker KL (1991) A shared promoter element regulates the expression ofthree steroidogenic enzymes. Mol Endocrinol 5:1552-1556 Richards JS (2001) New signaling pathways for hormones and cyclic adenosine 3', 5'-

monophosphate action in endocrine cells. Mol Endocrinol 15:209-218 Rittmaster RS (1994) Finasteride. New Eng J Med 330:120-125

Rheaume E, Sanchez F, Mebarki F, Gagnon E, Carel JC, Chaussain JL, Morel Y, Labrie F, Simard JN (1995) Identification and characterization of the G15D mutation found in a male patient with 3ß-hydroxysteroiddehydrogenase (3ß-HSD) deficiency-alteration of the putative NAD-binding domain oftype-II 3ß-HSD. Biochem 34:2893-2990 Rommerts FFG (1988) How much androgen is required for maintenance of spermatogenesis? J Endocr 116:7-9

Rommerts FFG (1992) Cell surface actions of steroids: A complementary mechanism for regulation of spermatogenesis? In: Spermatogenesis, fertilization and contraception (Molecular, cellular and endocrine events in male reproduction). Nieschlag E, Habenicht UF (eds), Schering Foundation Workshop 4, Springer Verlag, Berlin, pp 1-19 Rommerts FFG, Brinkmann AO (1981) Modulation of steroidogenic activities in testis Leydig cells. Mol Cell Endocr 21:15-28 Rommerts FFG, Cooke BA (1988) The mechanisms of action of luteinizing hormone. II. Transducing systems and biological effects. In: Hormones and their actions, part II (ed) Cooke BA, King RJB, van der Molen HJ. Elsevier Science Publishers BV (Biomedical Division), Amsterdam, pp 163-180

Rommerts FFG, van der Molen HJ (1989) Testicular steroidogenesis. In: The testis. Burger H, de

Kretser D (eds), 2nd edition, Raven Press, New York, pp 303-328 Saez JM (1989) Endocrine and paracrine regulation of testicular functions. Pediatr Adolesc Endocrinol 19:37-55

Saez JM (1994) Leydig cells: endocrine, paracrine and autocrine regulation. Endocr Rev 16: 574-626

Schlatt S, Meinhardt A, Nieschlag E (1997) Paracrine regulation of cellular interactions in the testis: factors in search of a function. Eur J Endocr 137:107-117 Seckl SR, Walker BR (2001) 11a-hydroxysteroid dehydrogenase type 1-a tissue specific amplifier of glucocorticoid action. Endocrinology 142:1371-1376 Selvage DJ, Rivier C (2003) Importance of the paraventricular nucleus of the hypothalamus as a component of a neural pathway between the brain and the testes that modulates testosterone secretion independently of the pituitary. Endocrinology 144:594-598 Setchel BP, Laurie MS, Flint APF, Heap RB (1983) Transport of free and conjugated steroids from the boar testis in lymph, venous blood and rete testis fluid. J Endocr 96:127-136 Shakil T, Ehsanul Hoque AN, Husain M, Belsham DD (2002) Differential regulation of gonadotropin-releasing hormone secretion and gene expression by androgen: membrane versus nuclear receptor activation. Mol Endocrinol 16:2592-2602 Sharpe RM (1993) Experimental evidence for Sertoli-germ cell and Sertoli- Ley dig cell interactions. In: The Sertoli cell. Russell LD, Griswold MD (eds), Cache River Press, Vienna, Il. pp.391-418

Simoncini T, Genazzani A (2003) Non-genomic actions of sex steroids. Eur J Endocrinol 148: 281-292

Simpson BJB, Wu FCW, Sharpe RM (1987) Isolation of human Leydig cells which are highly responsive to human chorionic gonadotropin. J Clin Endocrinol Metab 65:415-422 Smals AGH, Pieters GFFM, Lozekoot DC, Benraad TJ, Kloppenborg PWC (1980) Dissociated responses of plasma testosterone and 17-hydroxyprogesterone to single or repeated human chorionic gonadotropin administration in normal men. J Clin Endocrinol Metab 50: 190-193

Snyder SH, SklarPB, Pevsner J (1988) Molecular mechanisms of olfaction. J Biol Chem 263:1397113974

Sporn MB, Roberts AB (1988) Peptide growth factors are multifunctional. Nature 132: 217-219

Stocco DM, Clark BJ (1996) Regulation of the acute production of steroids in steroidogenic cells. Endocr Rev 17:221-244

Stocco DM (2001) Tracking the role of a star in the sky of the new millennium. Mol Endocrinol 15:1245-1254

Stocco DM (2002) Clinical disorders associated with abnormal cholesterol transport: mutations in the steroidogenic acute regulatory protein. Mol Cell Endocrinol 191:19-25 Strohman RC (1993) Ancient genomes, wise bodies, unhealthy people: limits of genetic thinking in biology and medicine. Perspec Biol Med 37:112-145 Teerds KJ, de Rooij DG, Rommerts FFG, Wensing CJG (1988) The regulation of the proliferation and differentiation of Leydig cell precursors after EDS administration of daily hCG treatment. J Androl 9:343-351

Themmen APN, Huhtaniemi IT (2000) Mutations of gonadotropins and gonadotropin receptors: elucidating the physiology and pathophysiology of pituitary-gonadal function. Endocr Rev 21:551-583

Trager L (1977) Steroidhormone: Biosynthese, Stoffwechsel, Wirkung, Springer Verlag, Berlin, pp 164-197

Ueda K, Okamura N, Hirai M, Tanigawara Y, Saeki T, Kioka N, Komano T, Hori R (1992) Human P-glycoprotein transports cortisol, aldosterone anddexamethasone but not progesterone. J Biol Chem 267:24248-24252 van den Akker EL, Koper JW, Boehmer AL, Themmen AP, Verhoef-Post M, Timmerman MA, Otten BJ, Drop SL, de Jong FH (2002) Differential inhibition of 17alpha-hydroxylase and 17,20-lyase activities by three novel missense CYP17 mutations identified in patients with P450c17 deficiency. J Clin Endocrinol Metab 87:5714-21 van Doorn LG, de Bruijn HWA, Galjaard H, van der Molen HJ (1974) Intercellular transport of steroids in the infused rabbit testis. Biol Reprod 10:47-53 van Haren L, Cailleau J, Rommerts FFG (1989) Measurement of steroidogenesis in rodent Leydig cells: a comparison between pregnenolone and testosterone production. Mol Cell Endocr 65:157-164

van Haren L, Flinterman JF, Orly J, Rommerts FFG (1992) Luteinizing hormone induction of the cholesterol side-chain cleavage enzyme in cultured immature rat Leydig cells: no role for insulin-like growth factor-I? Molec Cell Endocr 87:57-67 van Haren L, Flinterman JF, Rommerts FFG (1995) Inhibition ofluteinizinghormone-dependent induction of cholesterol side-chain cleavage enzyme in immature rat Leydig cells by Sertoli cell products. Eur J Endocrinol 132:627-634 van Loenen HJ, Flinterman JF, Rommerts FFG (1994) High affinity FSH receptor binding is a slowly nonreversible process that appears not to be important for rapid receptor activation. Endocrine 2:1031-1035

van Noort M, Rommerts FFG, van Amerongen A, Wirtz KWA (1988) Intracellular redistribution of SCP2 in Leydig cells after hormonal stimulation may contribute to increased pregnenolone production. Biochem Biophys Res Commun 154:60-65 van Straten NCR, Schoonus-Gerritsma GG, van Someren RG, Draaijer J, Adang AEP, Timmers CM, Hanssen RGJM, van Boeckel CAA (2002) The first orally low molecular weight agonists for the LH receptor: thienopyr(im)idines with therapeutic potential for ovulation induction. Chem Bio Chem 10:1023-1026 Wang C, Plymate E, NieschlagE, Paulsen CA (1981) Salivary testosterone in men. Further evidence of a direct correlation with free serum testosterone. J Clin Endocrinol Metab 53:1021-1024 Wang X, Walsh LP, Reinhart AJ, Stocco DM (2000) The role of arachidonic acid in steroidogenesis and steroidogenic acute regulatory (StAR) gene and protein expression. J Biol Chem 275:2020420209

Weusten JJAM, Smals AGH, Hofman JA, Kloppenborg PWC, Benraad ThJ (1987a) The sex pheromone precursor androsta-5,16 dien-3a ol is a major early metabolite in in vitro pregnenolone metabolism in human testicular homogenates. J Clin Endocrinol Metab 65:753-756 White PC, Mune T, Agarwal AR (1997) 116-hydroxysteroid dehydrogenase and the syndrome of apparent mineralocorticoid excess. Endocr Rev 18:135-156 Wiebe JP (1997) Nongenomic actions of steroids on gonadotropin release. Rec Prog Horm Res 52:71-102

Wilson JD (1988) Androgen abuse by athletes. Endocr Rev 9:181-199

Wilson JD, Griffin JE, Russell DW (1993) Steroid 5a-reductase 2 deficiency. Endocr Rev 14:577593

Yan W, Giudice LC (1999) Insulin-like growth factor II mediates the steroidogenic and growth promoting actions offollicle stimulating hormone on human ovarian preantral follicles cultured in vitro. J Clin Endocr Metab 84:1479-1482 Young J, Couzinet B, Chanson P, Brailly S, Loumay E, Schaison G (2000) Effects of human recombinant luteinizing hormone and follicle stimulating hormone in patients with acquired hypogonadotropic hypogonadism: study of Sertoli and Ley dig cell secretions and interactions. J Clin Endocrnol Metab 85:3239-3244 Zhang LH, Rodriguez H, Ohno S, Miller WL (1995) Serine phosphorylation of human P450c17 increases 17,20-lyase activity: Implications for adrenarche and the polycystic ovary syndrome. Proc Natl Acad Sci USA 92:10619-10623 Zhu Y, Rice CD, Pang Y, Pace M, Thomas P (2003a) Cloning, expression, and characterization of a membrane progestin receptor and evidence it is an intermediary in meiotic maturation offish oocytes. Proc Natl Acad Sci USA 100:2231-2236 Zhu Y, Bond J, Thomas P (2003b) Identification, classification, and partial characterization of genes in humans and other vertebrates homologous to a fish membrane progestin receptor. Proc Natl Acad Sci USA 100:2237-2242 Zuber MX, Simpson ER, Waterman MR (1986) Expression of bovine 17a-hydroxylase cytochrome P450cDNA in non-steroidogenic (COS1) cells. Science 234:1258-1260

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