Serum dihydrotestosterone DHT

Determination of dihydrotestosterone (DHT) does not play a role in routine monitoring oftestosterone replacement therapy, but maybe of importance in experimental use of testosterone preparations and monitoring biological effects of androgens. Due to the high 5a-reductase activity in skin, transdermal testosterone application is associated with increased serum DHT-levels; this applies especially to scrotal application. The DHT adds to the overall androgenicity of the preparation and a patient receiving transdermal treatment maybe well substituted clinically although his serum testosterone does not reflect this. In these cases occasional measurement of serum DHT maybe indicated (see Chapter 21).

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