SS Wolf and M Obendorf

Contents

20.1

Introduction

20.2

Mechanism of tissue selectivity

20.2.1

Metabolism of androgens in different tissues

20.2.2

AR interaction with DNA motifs in promoter of target genes

20.2.3

Protein/protein interaction of the AR

20.2.4

Tissue distribution of AR and AR-specific comodulators

20.2.5

Other approaches for selective actions

20.3

Search for tissue-specific androgens

20.3.1

Transcriptional reporter assays

20.3.2

Promoter specific regulation

20.3.3

In vivo test systems

20.3.4

The ideal tissue-selective androgen

20.4

Examples of tissue-specific androgens

20.4.1

General

20.4.2

Role of 5a-reduction

20.4.3

Mixed agonists/antagonists

20.5

Key messages

20.6

References

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