Testosterone an overview of biosynthesis transport metabolism and nongenomic actions

F.F.G. Rommerts

Contents

1.1

Introduction

1.2

Biosynthetic pathways

1.2.1

General

1.2.2

Steroids other than testosterone

1.2.3

Regulation of cholesterol side chain cleavage activity

1.2.4

Regulation of pregnenolone metabolism

1.3

Regulation of androgen synthesis by LH

1.3.1

General

1.3.2

Stimulatory actions of LH

1.3.3

Adaptation of Leydig cells

1.4

Regulation of androgen synthesis by factors other than LH

1.4.1

Locally produced factors

1.4.2

Other influences

1.5

Transport of steroids

1.5.1

Trafficking inside cells

1.5.2

Trafficking between the testicular compartments

1.5.3

Transport of androgens in the body

1.6

Metabolism of testosterone

1.7

Non-genomic effects of androgens

1.8

Key messages

1.9

References

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