Testosterone decanoate

Testosterone decanoate differs from testosterone undecanoate by one carbon atom in the ester side chain. It has been widely administered for many years as part of a mixture with shorter-action testosterone esters, however, it has not been available as a single preparation. To date there are no detailed studies published on the phar-macokinetics of administration of testosterone decanoate to hypogonadal men. Recently, intramuscular injections of 400 mg of testosterone decanoate were given four times every four weeks to normal men in a contraceptive study (Anderson etal. 2002). Endogenous testosterone was suppressed by concomitant administration

Fig. 14.14 Serum concentrations (mean ± SD) of testosterone after single injection of 1000 mg testosterone undecanoate in castor oil in 14 hypogonadal men (open circles) and during multiple injections with the same dose every 12 weeks. Broken lines indicate normal range of testosterone (adapted with permission from von Eckardstein and Nieschlag. 2002).

days

Fig. 14.14 Serum concentrations (mean ± SD) of testosterone after single injection of 1000 mg testosterone undecanoate in castor oil in 14 hypogonadal men (open circles) and during multiple injections with the same dose every 12 weeks. Broken lines indicate normal range of testosterone (adapted with permission from von Eckardstein and Nieschlag. 2002).

of etonogestrel implants. Nadir testosterone levels before the next injection were in the lower normal range, whereas serum levels were at the upper normal limit one week after injection. From these limited data it can be concluded that testosterone decanoate seems to have an improved pharmacokinetic profile over testosterone enanthate, but does not allow similar prolonged injection intervals of about 12 weeks, as demonstrated for testosterone undecanoate in hypogonadal men.

Hair Loss Prevention

Hair Loss Prevention

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