The androgen receptor molecular biology

Contents

2.1

Introduction

2.2

The androgen receptor gene

2.2.1

Genomic localization

2.2.2

Structure of the androgen receptor gene and its mRNA

2.2.3

Evolution of the androgen receptor

2.3

Functional domains of the androgen receptor

2.3.1

Amino terminal domain

2.3.2

DNA binding domain

2.3.3

Nuclear localization and hinge region

2.3.4

Ligand binding domain

2.3.5

Amino- and carboxyl-terminal interaction

2.4

Molecular mechanisms of androgen receptor action

2.4.1

Chaperones and co-chaperones in androgen receptor action

2.4.2

Androgen response elements

2.4.3

Co-activators and co-repressors

2.5

Cross-talk of androgen receptor and growth factor signaling pathways

2.5.1

Rapid non-transcriptional action of the androgen receptor

2.5.2

Ligand independent activation of the androgen receptor

2.6

Androgen receptor function in prostate cancer

2.6.1

Prostate development

2.6.2

Androgen receptor function and prostate disease

2.6.3

Androgen ablation therapy of prostate cancer

2.6.4

Androgen receptor involvement in failure of androgen ablation therapy

2.6.5

Androgen receptor as a therapy target in hormone-resistant prostate cancer

2.7

Pathogenicity of CAG repeat amplification in the androgen receptor

2.7.1

Kennedy syndrome (spinobulbar muscular atrophy - SBMA)

2.7.2

Characteristic features of the androgen receptor in SBMA

2.7.3

Animal models for SBMA

2.7.4

Mitigation of the SBMA phenotype

2.8

Key messages

2.9

References

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