Tissue distribution of AR and ARspecific comodulators

When hormones are effective acting on cells specifically, it is obvious that the corresponding receptor needs to be present to mediate transcriptional activity and induce expression of target genes. Therefore, the availability of AR is a prerequisite for the induction of androgen target genes. AR is widely distributed in mammalian reproductive and non-reproductive tissues but is predominantly expressed in testis, heart, prostate, muscle and ovary as determined by Northern blot analysis (Fig. 20.2).

While the abundance of comodulators is reflected by tissue-specific expression fingerprints, the coexpression of multiple comodulators in a single tissue appears to

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